Perikaryal neurofilament proteins.
نویسندگان
چکیده
منابع مشابه
Deregulation of Cdk5 in a Mouse Model of ALS Toxicity Alleviated by Perikaryal Neurofilament Inclusions
Recent studies suggest that increased activity of cyclin-dependent kinase 5 (Cdk5) may contribute to neuronal death and cytoskeletal abnormalities in Alzheimer's disease. We report here such deregulation of Cdk5 activity associated with the hyperphosphorylation of tau and neurofilament (NF) proteins in mice expressing a mutant superoxide dismutase (SOD1(G37R)) linked to amyotrophic lateral scle...
متن کاملInhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons.
Under normal conditions, the proline-directed serine/threonine residues of neurofilament tail-domain repeats are exclusively phosphorylated in axons. In pathological conditions such as amyotrophic lateral sclerosis (ALS), motor neurons contain abnormal perikaryal accumulations of phosphorylated neurofilament proteins. The precise mechanisms for this compartment-specific phosphorylation of neuro...
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Neurofilaments are the main components of intermediate filaments in neurons, and are expressed under three different subunit proteins, NFL, NFM and NFH. Neurofilaments act with microtubules and microfilaments to form and maintain the neuronal structure and cell shape. Phosphorylation is the main post-translational modification of neurofilaments, which influences their polymerization and depolym...
متن کاملNeurofilament proteins in the postnatal rat
Francisco R. López Picón Dept. of Pharmacology, Drug Development and Therapeutics, Institute of Biomedicine, University of Turku. Finnish Graduate School of Neuroscience. Neurofilament proteins (NFs) are the major components of the intermediate filaments of the neuronal cytoskeleton. The three different NF proteins; the low (NF-L), medium (NF-M), and dendrites. NF proteins play an important rol...
متن کاملStudies on the biosynthesis of neurofilament proteins
To determine whether the triplet polypeptides of neurofilaments arise by degradation of precursor, we studied the biosynthesis of neurofilament polypeptides both in vivo and in cell-free systems. Neurofilament-enriched fractions and polyribosomes were prepared from the same rabbit spinal cord homogenates. At 1 h after intracisternal administration of [34S]methionine, radiolabeled neurofilament ...
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ژورنال
عنوان ژورنال: SEIBUTSU BUTSURI KAGAKU
سال: 1986
ISSN: 0031-9082,1349-9785
DOI: 10.2198/sbk.30.29